If you’re looking for a probiotic but don’t know where to start, you’ve come to the right place. Read on to find out more about probiotics, how they might benefit you, and discover our top picks for the best probiotics in 2023. 

Potential Benefits of Taking Probiotics 

Adding a probiotic to your routine may help support:

  • Better Digestion*
  • Overall Gut Health* 
  • Less Bloat*
  • Immune Health*



  • Made in the USA, in a GMP-certified facility
  • "No questions asked" 90-day Money-Back-Guarantee
  • Contains 12 dynamic probiotic strains 
  • Contains PreforPro® prebiotic 
  • Third-party lab tested
  • With 31 billion CFUs
  • Only one capsule a day
  • Only available online
  • Sometimes runs out of stock

Primal Probiotics are formulated with 31 billion CUFs from 12 dynamic probiotic strains, including L. acidophilus, L. rhamnosus, L. casei, B. longum, B. bifidum, and Bacillus coagulans. It combines these with PreforPro® and FOS (Fructo-Oligosaccaride) prebiotics to support gut, immune, skin, and overall health.*

Our team liked that the product comes in easy-to-swallow, once-daily capsules, making them convenient to add to a supplement routine.

The formula is third-party lab-tested and made in the USA in a GMP-certified facility. To top it off, they’re backed by a 90-day money-back guarantee. Primal Probiotics’ pricing stands out, especially when you buy multiple bottles or sign up for their easy and convenient subscription service. 

The Bottom Line

Click to Shop Now

Make a Smarter Choice



1. Primal Probiotics

by Primal Harvest[1]

by Primal Harvest [1]

3732 Reviews of Primal Harvest 

Primal Probiotics

  • Made in the USA
  • Potent Probiotic Strains 
  • Patented PreforPro® Prebiotics
  • Money Back Guarantee
  • Ultimate Synbiotic Supplement

Click to Shop Now

© 2023

All Rights Reserved.  

Trademarks utilized on our website belong to their respective owners and no implied or expressed endorsement of our website or services is intended. Rankings can be affected by the relationship Smarter Choices has with our top picks.

[1] we have a financial relationship with some of our top picks and partners

Our Choice

What Is A Probiotic?

Probiotics are live bacteria and yeast that live in your gut microbiome.

There are many different benefits associated with probiotics, from supporting digestion, weight, and regularity to supporting a healthy immune system.* 

Whenever you see the term “gut microbiome,” it’s referring to all of the microorganisms living within your gut. Some of them may be potentially harmful, so-called “bad” bacteria. On the other hand, some are thought to be beneficial, often called “good” or “friendly” bacteria, aka probiotics. [1, 2, 3, 4] 

Try To Avoid...

*Individual results may vary


*Always consult your personal physician for an accurate diagnosis and treatment plan.

*These statements are not intended to diagnose, treat, cure or prevent any disease.

*These statements have not been evaluated by the FDA Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. The information provided by this website or this company is not a substitute for a face-to-face consultation with your physician and should not be construed as individual medical advice. The testimonials on this website are individual cases and do not guarantee that you will get the same results. All content, including text, graphics, images and information, contained on or available through this web site is for general information purposes only. 

Learn more

Best Probiotics Of 2023

Privacy Policy

Everyone's needs are different, but some people who may benefit from taking a probiotic supplement are people who:

  • Struggles with regularity*
  • Finds it hard to consume probiotics through food*
  • Often experiences digestive issues*
  • Has a difficult time passing stool*
  • Feels bloated or constipated on a regular basis*
  • Experiences skin issues*
  • Often feels run-down or sluggish*

Our Criteria For Selecting The Best Probiotics:

Must Haves:

What To Avoid:

  • Trying to select the cheapest
  • Not checking the label
  • High serving size
  • Extremely high or low price
  • Inflated CFU numbers
  • Cheap Probiotic Strains
  • Contains high quality probiotic strains
  • Includes prebiotics
  • 1 capsule serving size
  • Fair price
  • Great customer service & return policy
  • Made in USA
  • Third-party laboratory tested



  • Delayed release capsules 
  • Made in the USA 
  • Low entry price point
  • 60-day money back guarantee 
  • Poor Quality Control - Products sometimes arrive already expired

Click to Shop Now

2. Ultimate Flora Probiotics

by RenewLife

This product is a great budget probiotic. With 30 BIL CFU & 12 Probiotic Strains, you are getting a quality product at a decent price point. The biggest issue we saw with this product was with the distribution. Some of our panel reported receiving expired products. This is a serious problem as taking a probiotic that was not shipped or stored properly is almost like taking sugar pills. 



  • No artificial colors or flavors 
  • GMP certified 
  • 1 tablet serving size
  • Tablet form vs. delayed release capsules 
  • Some users reported stomach issues 
  • Contains only 1 probiotic strain 

Click to Shop Now

3. Probiotics

by Nature’s Bounty

Nature’s Bounty probiotics is a low-cost, GMP-certified supplement formulated to support digestive health with over 100 million active Lactobacillus Acidophilus. This product comes in tablet form, which may be a downside for some since it does not have a delayed release feature. Also, though the serving size is only 1 tablet, users reported having to double their dosage in order to see any results. Finally, Nature’s Bounty probiotics come in third on our list due to reports of some users having upset stomachs.



  • 1 capsule serving size
  • Includes inulin (chicory root)
  • Only contains 1 probiotic strain
  • Only 12 billion CFUs
  • No Bifido strains 

Click to Shop Now

4. Digestive Daily Probiotic

by Culturelle

Digestive Daily Probiotic by Culturelle is a probiotic formula that includes 12 billion CFUs of the probtioc strain Lactobacillus rhamnosus GG. Our team liked that they include the prebiotic inulin in the formula and that it comes in a one-capsule serving size. However, the fact that this formula only contains one probiotic strain places it fourth on our list.*



  • Once-daily capsule 
  • High CFU count and number of probiotic strains
  • Include digestive enzymes 
  • No 90-day money-back guarantee
  • No prebiotics

Click to Shop Now

5. Raw Probiotics

by Garden of Life

Raw Probiotics by Garden of Life is a once-daily probiotic supplement that includes 100 billion CFUs of both Lacto and Bifido probiotic strains. We liked that this product includes a diverse selection of strains and has a high CFU count. While we felt this product was relatively comparable to the other products on this list, the brand does not offer a 90-day money back guarantee which our team found disappointing. Additionally, although we liked that the formula includes a digestive blend, our team noted that it did not include prebiotics.*

  • Healthy Weight Management* 
  • Increased Energy* 
  • Healthier Skin*
  • Occasional Constipation and Excess Gas*

The Bottom Line





The Bottom Line



The Bottom Line



The Bottom Line

1. Integrative HMP (iHMP) Research Network Consortium. “The Integrative Human Microbiome Project: dynamic analysis of microbiome-host omics profiles during periods of human health and disease.” Cell host & microbe vol. 16,3 (2014): 276-89. doi:10.1016/j.chom.2014.08.014

2. Sender, Ron et al. “Revised Estimates for the Number of Human and Bacteria Cells in the Body.” PLoS biology vol. 14,8 e1002533. 19 Aug. 2016, doi:10.1371/journal.pbio.1002533

3. Durack, Juliana, and Susan V Lynch. “The gut microbiome: Relationships with disease and opportunities for therapy.” The Journal of experimental medicine vol. 216,1 (2019): 20-40. doi:10.1084/jem.20180448

4. Al Bander, Zahraa et al. “The Gut Microbiota and Inflammation: An Overview.” International journal of environmental research and public health vol. 17,20 7618. 19 Oct. 2020, doi:10.3390/ijerph17207618


Allaker RP, Stephen AS. Use of Probiotics and Oral Health. Curr Oral Health Rep. 2017;4(4):309-318. doi:10.1007/s40496-017-0159-6. 

Bifidobacterium lactis, UABla-12™. Chr. Hansen. Updated 2021. Accessed June 7 2021. 

Cani PD, Delzenne NM. Gut microflora as a target for energy and metabolic homeostasis. Curr Opin Clin Nutr Metab Care. 2007;10(6):729-734. doi:10.1097/MCO.0b013e3282efdebb

Cerdó T, García-Santos JA, G Bermúdez M, Campoy C. The Role of Probiotics and Prebiotics in the Prevention and Treatment of Obesity. Nutrients. 2019;11(3):635. Published 2019 Mar 15. doi:10.3390/nu11030635

Febvre HP, Rao S, Gindin M, Goodwin NDM, Finer E, Vivanco JS, Lu S, Manter DK, Wallace TC, Weir TL. PHAGE Study: Effects of Supplemental Bacteriophage Intake on Inflammation and Gut Microbiota in Healthy Adults. Nutrients. 2019; 11(3):666. doi:10.3390/nu11030666. 

Grubb DS, Wrigley SD, Freedman KE, Wei Y, Vazquez AR, Trotter RE, Wallace TC, Johnson SA, Weir TL. PHAGE-2 Study: Supplemental Bacteriophages Extend Bifidobacterium animalis subsp. lactis BL04 Benefits on Gut Health and Microbiota in Healthy Adults. Nutrients. 2020; 12(8):2474. doi: 10.3390/nu12082474. 

Helli B, Kavianpour M, Ghaedi E, Dadfar M, Haghighian HK. Probiotic effects on sperm parameters, oxidative stress index, inflammatory factors and sex hormones in infertile men. Hum Fertil (Camb). 2022;25(3):499-507. doi:10.1080/14647273.2020.1824080

Hill D, Sugrue I, Tobin C, Hill C, Stanton C, Ross RP. The Lactobacillus casei Group: History and Health Related Applications. Front Microbiol. 2018;9:2107. Published 2018 Sep 10. doi:10.3389/fmicb.2018.02107. 

Kim CS, Cha L, Sim M, et al. Probiotic Supplementation Improves Cognitive Function and Mood with Changes in Gut Microbiota in Community-Dwelling Older Adults: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial. J Gerontol A Biol Sci Med Sci. 2021;76(1):32-40. doi:10.1093/gerona/glaa090

Kim HJ, Vazquez Roque MI, Camilleri M, Stephens D, Burton DD, Baxter K, Thomforde G and Zinsmeister AR (2005), A randomized controlled trial of a probiotic combination VSL# 3 and placebo in irritable bowel syndrome with bloating. J Neurogastroenterol Motil. 2005;17:687-696.  

Kim SK, Guevarra RB, Kim YT, et al. Role of Probiotics in Human Gut Microbiome-Associated Diseases. J Microbiol Biotechnol. 2019;29(9):1335-1340. doi:10.4014/jmb.1906.06064. 

Lactospore FAQ. Sabinsa Corporation. Updated 2021. Accessed June 7 2021. 

Markowiak P, Śliżewska K. Effects of Probiotics, Prebiotics, and Synbiotics on Human Health. Nutrients. 2017;9(9):1021. Published 2017 Sep 15. doi:10.3390/nu9091021.

Marotta A, Sarno E, Del Casale A, et al. Effects of Probiotics on Cognitive Reactivity, Mood, and Sleep Quality. Front Psychiatry. 2019;10:164. Published 2019 Mar 27. doi:10.3389/fpsyt.2019.00164

Macfarlane GT, Cummings JH. Probiotics, infection and immunity. Curr Opin Infect Dis. 2002;15(5):501-506. doi:10.1097/00001432-200210000-00008. 

Maldonado Galdeano C, Cazorla SI, Lemme Dumit JM, Vélez E, Perdigón G. Beneficial Effects of Probiotic Consumption on the Immune System. Ann Nutr Metab. 2019;74(2):115-124. doi:10.1159/000496426.  

Meini S, Laureano R, Fani L, Tascini C, Galano A, Antonelli A, Rossolini GM. Breakthrough Lactobacillus rhamnosus GG bacteremia associated with probiotic use in an adult patient with severe active ulcerative colitis: case report and review of the literature. Infection. 2015 Dec;43(6):777-81. doi: 10.1007/s15010-015-0798-2. Epub 2015 May 30. PMID: 26024568.  

Nichols AW. Probiotics and athletic performance: a systematic review. Curr Sports Med Rep. 2007;6(4):269-273.

Nobaek S, Johansson ML, Molin G, Ahrné S, Jeppsson B. Alteration of intestinal microflora is associated with reduction in abdominal bloating and pain in patients with irritable bowel syndrome. Am J Gastroenterol. 2000;95(5):1231-1238. doi:10.1111/j.1572-0241.2000.02015.x. 

Plaza-Díaz J, Ruiz-Ojeda FJ, Vilchez-Padial LM, Gil A. Evidence of the Anti-Inflammatory Effects of Probiotics and Synbiotics in Intestinal Chronic Diseases. Nutrients. 2017;9(6):555. Published 2017 May 28. doi:10.3390/nu9060555. 

Reid G, Jass J, Sebulsky MT, McCormick JK. Potential uses of probiotics in clinical practice. Clin Microbiol Rev. 2003;16(4):658-672. doi:10.1128/CMR.16.4.658-672.2003

Tubelius P, Stan V, Zachrisson A. Increasing work-place healthiness with the probiotic Lactobacillus reuteri: a randomised, double-blind placebo-controlled study. Environ Health. 2005;4:25. Published 2005 Nov 7. doi:10.1186/1476-069X-4-25.  

Vighi G, Marcucci F, Sensi L, Di Cara G, Frati F. Allergy and the gastrointestinal system. Clin Exp Immunol. 2008;153 Suppl 1(Suppl 1):3-6. doi:10.1111/j.1365-2249.2008.03713.x. 

Wang J, Ji H. Influence of Probiotics on Dietary Protein Digestion and Utilization in the Gastrointestinal Tract. Curr Protein Pept Sci. 2019;20(2):125-131. doi:10.2174/1389203719666180517100339.

Whorwell PJ, Altringer L, Morel J, et al. Efficacy of an encapsulated probiotic Bifidobacterium infantis 35624 in women with irritable bowel syndrome. Am J Gastroenterol. 2006;101(7):1581-1590. doi:10.1111/j.1572-0241.2006.00734.x. 

Wu HJ, Wu E. The role of gut microbiota in immune homeostasis and autoimmunity. Gut Microbes. 2012;3(1):4-14. doi:10.4161/gmic.19320.  

Yan F, Polk DB. Probiotics and immune health. Curr Opin Gastroenterol. 2011;27(6):496-501. doi:10.1097/MOG.0b013e32834baa4d.  

Mei Z, Li D. The role of probiotics in vaginal health. Front Cell Infect Microbiol. 2022;12:963868. Published 2022 Jul 28. doi:10.3389/fcimb.2022.963868

Cribby S, Taylor M, Reid G. Vaginal microbiota and the use of probiotics. Interdiscip Perspect Infect Dis. 2008;2008:256490. doi:10.1155/2008/256490

van de Wijgert J, Verwijs MC. Lactobacilli-containing vaginal probiotics to cure or prevent bacterial or fungal vaginal dysbiosis: a systematic review and recommendations for future trial designs. BJOG. 2020;127(2):287-299. doi:10.1111/1471-0528.15870

Lehtoranta L, Ala-Jaakkola R, Laitila A, Maukonen J. Healthy Vaginal Microbiota and Influence of Probiotics Across the Female Life Span. Front Microbiol. 2022;13:819958. Published 2022 Apr 8. doi:10.3389/fmicb.2022.819958

Borges S, Silva J, Teixeira P. The role of lactobacilli and probiotics in maintaining vaginal health. Arch Gynecol Obstet. 2014;289(3):479-489. doi:10.1007/s00404-013-3064-9

Top Probiotic Supplements Of 2023

What To Look For

What To Avoid

Important Criteria